Anti-ADAM10 Rabbit Polyclonal Antibody

Supplier: GeneTex

GTX21997
89361-124EA 781.14 CAD
89361-124
Anti-ADAM10 Rabbit Polyclonal Antibody
Antibodies
Proinflammatory cytokine tumor necrosis factor-a (TNF-a)contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, Respectively, (1,2,4). ADAM10 mRNA is expressed in a variety of human and bovine tissues (1,4).

  • For WB: Use at a concentration of 1:500-1:2,000.ICC/IF:10ug/ml.Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Type: Primary
Antigen: ADAM10
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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