Anti-BID Rabbit Polyclonal Antibody

Supplier: GeneTex

89361-232EA 624.19 CAD
Anti-BID Rabbit Polyclonal Antibody
Bid, a BH3 domain-containing pro-apoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent pro-apoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.

IHC-Fr: Use at a concentration of 20 - 40 ?g/ml. IP: Use at a concentration of 5 - 10 ?g/ml. WB: Use at a concentration of 1 ?g/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: BID
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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