Anti-BID Rabbit Polyclonal Antibody

Supplier: GeneTex

GTX22561
89361-286EA 624.19 CAD
89361-286
Anti-BID Rabbit Polyclonal Antibody
Antibodies
Bid, a BH3 domain-containing pro-apoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent pro-apoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In the animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.

IP: Use at a concentration of 20 ?g/ml.WB:Use at a concentration of 0.5-5 µg/ml.Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: BID
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse
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