Anti-PMAIP1 Rabbit Polyclonal Antibody

89359-814EA 518.15 CAD
Anti-PMAIP1 Rabbit Polyclonal Antibody
Recently a BH3 only member of the Bcl2 family has been identified in human and mouse and designated as Noxa (for damage). The expression of the Noxa gene involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53 deficient thymocytes. Noxa cDNA codes for a 103 amino acid protein. The co-immunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl2 family, such as, BclXL and Mcl1. It has also been shown that blocking the endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation induced apoptosis suggesting that Noxa may represent a mediator of p53 dependent apoptosis.

Type: Primary
Antigen: PMAIP1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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