Anti-CD40 Goat Polyclonal Antibody

89355-932EA 510.09 CAD
Anti-CD40 Goat Polyclonal Antibody
CD40 is a transmembrane glycoprotein mainly expressed on the surface of B cells and is also expressed on monocytes, dendritic cells, endothelial cells, and epithelial cells. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 ligand (CD40L, CD154, gp39, TRAM) belongs to the TNF gene family and is expressed more widely than activated CD4+ T cells. Following interaction with CD40L, CD40 mediates a number of major immunoregulatory functions, is central to the control of thymus-dependent humoral immunity and may be critical in the development of cell-mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphoma and to induce the death of transformed cells of mesenchymal or epithelial origin. In their resting state up to 50% of B cells may express CD40L in their cytoplasm, but not on the surface and this cytoplasmic CD40L is readily released as a soluble receptor. The proportion of expressing cells and the amount of CD40L expressed is increased by signaling through immunoglobulin (Ig) or CD38. The signal transduction pathways triggered through CD40 have not yet been fully delineated. Early biochemical events include activation of Ras, of Lyn and Syk protein tyrosine kinases, phosphorylation and activation of phospholipase C2 and phosphoinositide 3 kinase, and induction of mitogen-activated protein kinases. Activation processes seem to be initiated by association of the CD40 receptor with signaling molecules of the TRAF family.

Type: Primary
Antigen: CD40
Clonality: Polyclonal
Clone: 0
Conjugation: Unconjugated
Host: Goat
Isotype: IgG
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