Anti-MMP14 Rabbit Polyclonal Antibody

Supplier: GeneTex

89358-584EA 699.2 CAD
Anti-MMP14 Rabbit Polyclonal Antibody
The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane-type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimers, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.

ELISA: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. WB: Use at a dilution of 1/2000. Detects a band of approximately 65 (pro-form) and 63 kDa (active form). MMP14 (MT1MMP) is elevated in several tumor cell lines and is constitutively produced by some normal cell lines. Treatment of cells with concanavalin A or the phorbal ester TPA stimulates production of MT1MMP in some cell types. The enzyme can be recovered in cell lysates. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: MMP14
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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