Anti-EGLN1 Rabbit Polyclonal Antibody

89363-592EA 492.47 CAD
Anti-EGLN1 Rabbit Polyclonal Antibody
PHD2 protein catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. In the presence of oxygen, PHD2 converts specific prolyl residues in HIF alpha to hydroxyproline, leading to HIF alpha proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF levels are stable. This results in increased angiogenesis as HIF1 alpha regulates the expression of many angiogenesis-related genes. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas PHD2 is an intracellular protein. Inhibitors of PHD may be useful for the treatment of anemia and ischemic disease.

Type: Primary
Antigen: EGLN1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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