Anti-Activin Receptor LIKE Kinase 1 Goat Polyclonal Antibody

89354-470EA 520.32 CAD
Anti-Activin Receptor LIKE Kinase 1 Goat Polyclonal Antibody
The TGF-beta superfamily of ligands exerts its biological activity by binding to heteromeric receptor complexes two types (I and II) of the serine/threonine kinases. Type II receptors are constitutively active kinases, which phosphorylate type I receptors after ligand binding. In turn, the activated type I kinases phosphorylate downstream signaling molecules including the various smads. Seven type I receptors, also termed activin receptor-like kinase (ALK), have been isolated from mammals. The physiological ligand for ALK1 is currently unknown. It is suggested that TGF-beta 1 and TGF-beta 3 can activate chimeric ALK1. ALK1, like the other type I receptors, contains a cysteine rich domain with conserved cysteine spacing in the extracellular region and a glycine and serine rich domain preceding the kinase domain. The reduced human ALK1 monomer has a calculated molecular mass of approximately 37.3 kDa. Due to glycoslyation, the recombinant human protein migrates as a 50-55 kDa protein in SDS-PAGE under reducing conditions. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular domains. ALK1 is highly expressed in endothelial cells and other vascular tissues. Mutations in ALK1 are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting an important role for ALK1 in the control of blood vessel development and repair.

Type: Primary
Antigen: Activin Receptor LIKE Kinase 1
Clonality: Polyclonal
Host: Goat
Isotype: IgG
Reactivity: Human
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