Anti-APE Rabbit Polyclonal Antibody

Supplier: Genetex
89359-896EA 921 CAD
Anti-APE Rabbit Polyclonal Antibody
Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme that plays an important role in numerous, cellular functions. APE is responsible for repairing abasic sites in DNA and in regulating the redox state of other proteins that play roles in oxidative signaling, transcription factor regulation (Fos, Jun, NFkB, Myb, HIF1 alpha, CREB, Pax), cell cycle control (p53), and apoptosis. Altered levels of APE have also been found in some cancers. The most common form of DNA damage is the creation of abasic sites which are brought about through spontaneous loss or oxidative DNA damage, through chemically initiated hydrolysis (chemotherapy), ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA glycosylases.

WB: Use at a concentration of 1 - 2 ?g/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 35 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: APE
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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