Anti-Abeta Mouse Monoclonal Antibody [clone: 4H308]

Supplier: GeneTex

89360-302EA 732.3 CAD
Anti-Abeta Mouse Monoclonal Antibody [clone: 4H308]
The cerebral and vascular plaques associated with Alzheimer's disease (AD) are mainly composed of amyloid beta peptides (Ab). Ab is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Ab [1-40], Ab [1-42], and Ab [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma secretase during the last APP processing step. Ab [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. Ab antibodies and peptides have been developed as tools for elucidating the biology of AD.

WB: 1/1000. Detects a band of approximately 4.5 kDa (predicted molecular weight: 4.5 kDa). IHC-P: 1/250 detects amyloid b in human brain sections. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: Abeta
Clonality: Monoclonal
Clone: 4H308
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG
Reactivity: Human
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