Anti-POMC Mouse Monoclonal Antibody [clone: B31.15]

Supplier: GeneTex

89361-020EA 624.53 CAD
Anti-POMC Mouse Monoclonal Antibody [clone: B31.15]
Corticotropin (ACTH), synthesized by the anterior pituitary gland, stimulates the adrenal cortex. Human ACTH has a molecular weight of 4,541 and contains 39 amino acids . It has structural similarities to melanotropin (melanocyte-stimulating hormone; MSH). Human beta-melanotropin has 22 amino acid residues and a molecular weight of 2,661. Work on the structure of the ACTH gene by restriction enzyme techniques showed that 6 hormones are derived from one gene: ACTH, lipotropin, alpha-MSH, beta-MSH, endorphin, and one other. Thus, extensive amino acid differences between these hormones were not adequate evidence for their being distinct. ACTH and beta-lipotropin (beta-LPH) are derived from a large precursor peptide. Each of these hormones is known to include smaller peptides having distinct biologic activities: alpha-melanotropin (alpha-MSH) and corticotropin-like intermediate lobe peptide (CLIP) are formed from ACTH; gamma-LPH and beta-endorphin are peptide components of beta-LPH. Beta-MSH is contained within gamma-LPH. The precursor peptide was called proopiomelanocortin (POMC).

IF: Use at an assay dependant concentration. IHC-Fr: Use at an assay dependant concentration. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: POMC
Clonality: Monoclonal
Clone: B31.15
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1
Reactivity: Human
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