Anti-BNP Mouse Monoclonal Antibody [clone: 2G9]

Supplier: GeneTex

89350-904EA 624.64 CAD
Anti-BNP Mouse Monoclonal Antibody [clone: 2G9]
Brain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. BNP belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic peptides (eleven of the 17 amino acid residues are homologous in the ring of each of the natriuretic peptides, see fig. 18). BNP is a 32 amino acid peptide with disulfide bond between the cystein residues Cys10 and Cys26. In earlier studies it has been demonstrated that BNP concentration in blood increases with the severity of congestive heart failure. Quantitative measurement of BNP in blood provides an objective indicator of congestive heart failure severity.

ELISA: Use at an assay dependent dilution. EIA: Use at an assay dependent dilution. Can be used for proBNP immunoassay development in combination with anti-NT-proBNP MAbs; GTX13111 Mouse monoclonal [5B6] to proBNP , GTX13115 Mouse monoclonal [15F11] to proBNP and GTX13059 Mouse monoclonal [11D1] to proBNP . Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: BNP
Clonality: Monoclonal
Clone: 2G9
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1
Reactivity: Human
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