Anti-C35 Rabbit Monoclonal Antibody

89364-398EA 556.26 CAD
Anti-C35 Rabbit Monoclonal Antibody
C35 (C17orf37, XTP4, ORB3) is a novel cancer marker encoded by a gene located on chromosome 17, adjacent to the Her2 oncogene. Similar to Her2, C35 is overexpressed in cancer tissues, in particular breast and prostate cancer tissues, but not in the normal homolog tissues. The functional role of C35 has not been identified. However, an analysis of predicted functional motifs of the gene product suggests that it may play a role in signal transduction and redox-related process . In prostate cancer, the downregulation of C35 leads to suppression of both Akt phospholyation and NF-kappa B activity. This suggests C35 might be involved in increasing the invasive potential of prostate cancer cells by NF-kappaB-mediated downstream target genes . Along with its tumor specific expression, C35 expression is persistent throughout tumor progression. Therefore, C35 is considered as an ideal biomarker for the diagnosis of both early-stage and late-stage cancer, and a possible anti-cancer therapeutic target .

Type: Primary
Antigen: C35
Clonality: Monoclonal
Conjugation: Unconjugated
Host: Rabbit
Reactivity: Human
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