Anti-CAPN1 Rabbit Monoclonal Antibody

89364-452EA 556.26 CAD
Anti-CAPN1 Rabbit Monoclonal Antibody
Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpain cleaves many biologically important proteins and thus serves as a key regulator of many cellular functions . For example, it cleaves proteins like EGFR and alpha-spectrin, thus serving as a key regulator of cell proliferation . Calpain activity is modulated in vivo by an endogenous inhibitor called calpastatin, which can be cleaved by calpain . There are 2 distinct molecular forms of calpain, calpains 1 and 2, which differ in the quantity of Ca2+ required. Each form is composed of a large catalytic subunit and a small regulatory subunit . The full length isoform of calpain 1 (80 kDa) has greater Ca2+ affinity than the autoproteolytically cleaved isoform (75 kDa, at leucine 28) . Calpain 1 (large subunit) is a Ca2+-regulated thiol protease that catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction .

Type: Primary
Antigen: CAPN1
Clonality: Monoclonal
Conjugation: Unconjugated
Host: Rabbit
Reactivity: Human
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