Anti-CASP8 Mouse Monoclonal Antibody

89361-282EA 470.87 CAD
Anti-CASP8 Mouse Monoclonal Antibody
Caspase 8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase 8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated Caspase 8 is able to cleave and activate downstream caspases, such as Caspase 3, 6, 7 and a death agonist member of the Bcl-2/Bcl-xL family, Bid, leading to apoptosis.

Type: Primary
Antigen: CASP8
Clonality: Monoclonal
Conjugation: Unconjugated
Host: Mouse
Reactivity: Human
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