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Anti-CD3 Mouse Monoclonal Antibody [clone: OKT3]
Anti-CD3 Mouse Monoclonal Antibody [clone: OKT3]
Catalog #: 89366-656
Supplier:  Genetex
Anti-CD3 Mouse Monoclonal Antibody [clone: OKT3]
Catalog #: 89366-656
Supplier:  Genetex
Price
$1,019.48
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Unit of Measure Each (100µG)
Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
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Specifications

  • Antibody type:
    Primary
  • Antigen name:
    CD3 Molecule
  • Clonality:
    Monoclonal
  • Clone:
    OKT3
  • Host:
    Mouse
  • Isotype:
    IgG2a
  • Reactivity:
    Human
  • Antigen symbol:
    CD3
  • Conjugation:
    Unconjugated
  • Flow cytometry:
    Yes
  • ImmunoChemistry:
    Yes
  • Size:
    100 µg
  • Storage buffer:
    Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. Endotoxin level is less than 10 EU/mg of the protein, as determined by the LAL test.
  • Storage temperature:
    –20 °C
  • Immunogen:
    Commercially sensitive information
  • Tested applications:
    Fluorescence-Activated Cell Sorting, Functional Assay
  • Cat. no.:
    89366-656

Specifications

About this item

CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.Entrez Gene: 11q23

Type: Primary
Antigen: CD3
Clonality: Monoclonal
Clone: OKT3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity:

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