Anti-CD322 Rat Monoclonal Antibody

89360-246EA 462.34 CAD
Anti-CD322 Rat Monoclonal Antibody
Junctional adhesion molecule 2 (JAM2), also know as JAMC, is a cell adhesion molecule (CAM). JAM2 is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM2 belongs together with JAMA (JAM or JAM1) and JAMB (VEJAM or JAM3) to a family of adhesion proteins with a VC2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell to cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM2 is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM2 expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney. In humans, JAM2 expression is not restricted to endothelial cells, but is also expressed on human lymphocytes.

Type: Primary
Antigen: CD322
Clonality: Monoclonal
Clone: 0
Conjugation: Unconjugated
Host: Rat
Isotype: IgG2a
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