Anti-CD34 Mouse Monoclonal Antibody [clone: 4H11(APG)]

Supplier: Genetex

GTX18225
89360-430EA 662.16 CAD
89360-430
Anti-CD34 Mouse Monoclonal Antibody [clone: 4H11(APG)]
Antibodies
The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis.

FACS: Use 20?l for 100?l human blood cells. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: CD34
Clonality: Monoclonal
Clone: 0
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity:
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