Anti-CHK1 Rabbit Monoclonal Antibody

89364-328EA 556.26 CAD
Anti-CHK1 Rabbit Monoclonal Antibody
Chk1 is a serine/threonine-protein kinase involved in cell cycle arrest when DNA damage has occurred, and it plays an important role in DNA damage checkpoint, embryonic development and tumor suppression . Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345 . Activated Chk1 can inactivate cdc25c through phosphorylation at Serine 216 (3,4 ). Phosphorylation of cdc25c prevents activation of the CDC2-cyclin B complex and prevents entry into M-phase .

Type: Primary
Antigen: CHK1
Clonality: Monoclonal
Conjugation: Unconjugated
Host: Rabbit
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