Anti-C-JUN Rabbit Polyclonal Antibody

Supplier: Genetex

GTX11914

89358-974EA 923.02 CAD

89358-974

Anti-C-JUN Rabbit Polyclonal Antibody

Antibodies

The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. c-Jun (previously known as the Fos-binding protein p39) and c-Fos form a complex in the nucleus. AP 1 (activating protein-1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto-oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

WB: Use at a dilution of 1:100 to 1:250 is recommended. Detects a band of approximately 41 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: C-JUN
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity:

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