Anti-CORO1A Goat Polyclonal Antibody

Supplier: GeneTex
89360-066EA 923.94 CAD
Anti-CORO1A Goat Polyclonal Antibody
Coronin 1 was first isolated from Dictyostelium, but similar proteins have been identified in many species and individual cell types. The coronin-like protein in yeast promotes actin polymerization and also interacts with microtubules. Dictyostelium mutants lacking coronin are impaired in cytokinesis and all actin-mediated processes. Analysis of coronin-GFP (green-fluorescent protein) fusions and knockout mutants shows that coronin participates in the remodelling of the cortical actin cytoskeleton that is responsible for phagocytosis and macropinocytosis. Likewise, in mammalian neutrophils, a coronin-like protein is also associated with the phagocytic apparatus. Coronin 1 binds actin (by similarity) and is found in noninfected macrophages, localised to the cortical microtubule network; in mycobacteria-infected macrophages, progressively relocalized and retained around the mycobacterial phagosomes. Coronin1/TACO is expressed in brain, thymus, spleen, bone marrow and lymph node. Low expression observed in lung and gut.

Peptide ELISA: Use at a dilution of 1/16000. WB: Use at a concentration of 0.25 - 1 ?g/ml. Detects a band of approximately 60 kDa in Molt-4 and Jurkat lysates (predicted molecular weight: 53 kDa according to NP_009005). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: CORO1A
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Goat
Isotype: IgG
Reactivity: Human, Mouse, Dog, Rat, Bovine
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