Anti-CK5 Mouse Monoclonal Antibody [clone: 16.4]

Supplier: GeneTex
89360-224EA 869.65 CAD
Anti-CK5 Mouse Monoclonal Antibody [clone: 16.4]
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non-keratinizing cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis.Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.

IHC: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Detects bands of approximately 58 and 50 kDa corresponding to cytokeratins 5 and 14 respectively. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: CK5
Clonality: Monoclonal
Clone: 16.4
Conjugation: Unconjugated
Host: Mouse
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