Anti-DR4 Mouse Monoclonal Antibody [clone: DR-4-02]

Supplier: GeneTex
GTX14738
89360-054EA 592.76 CAD
89360-054
Anti-DR4 Mouse Monoclonal Antibody [clone: DR-4-02]
Antibodies
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor 1(TRAIL R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF kB activation in many tissues and cells.

Recommended Starting Dilutions:Flow Cytometry: 1/50 - 1/100Not tested in other applications. Optimal dilution / concentration should be determined by the end user.

Type: Primary
Antigen: DR4
Clonality: Monoclonal
Clone: DR-4-02
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human
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