Anti-DNM1 Mouse Monoclonal Antibody [clone: 4E+67]

Supplier: GeneTex
89360-004EA 923.07 CAD
Anti-DNM1 Mouse Monoclonal Antibody [clone: 4E+67]
Dynamin is a 100 kDa GTP binding protein that was first identified as a protein able to bind microtubules. A mutation in the Drosophila gene shits, encoding a dynamin homologue, prevents synaptic vesicle recycling and causes temperature-sensitive paralysis, implicating dynamin in the formation of coated vesicles. Dynamin may mediate vesicle formation by assembling into a ring structure around the necks of invaginated coated pits that may eventually lead to the closure of the neck and formation of vesicles. Amphiphysin, dynamin, clathrin and AP2 form a complex during synaptic vesicle endocytosis, which is regulated by the phosphorylated state of different components in this complex. To date, three genes have been found to encode dynamin isoforms. Dynamin 1 is neuronal specific, Dynamin 2 is ubiquitously expressed and Dynamin 3 localizes to testis, brain and lung.

IHC: Use at an assay dependent dilution. Staining of formaldehyde perfused and fixed rat brain shows synaptic immunofluorescence. IP: Use at an assay dependent dilution. WB: Use at a concentration of 0.5 mg/ml. Predicted molecular weight: 97 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: DNM1
Clonality: Monoclonal
Clone: 4E+67
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG
Reactivity: Bovine
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