Anti-EGFR Rabbit Monoclonal Antibody

GTX61503
89364-008EA 556.26 CAD
89364-008
Anti-EGFR Rabbit Monoclonal Antibody
Epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor (EGF), affects cell growth and differentiation . Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor . The carboxy terminal tyrosine residues on EGFR, Tyr 1068, Tyr 1148, and Tyr 1173, are the major sites of autophosphorylation, which occurs as a result of EGF binding . Once activated, EGFR phosphotyrosines Y-1068 and Y-1173 mediate the binding of Grb2 to the EGFR. Addtionally, phosphotyrosine Y-1173 is a major binding site for SHC on the EGFR .

Type: Primary
Antigen: EGFR
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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