Anti-EGFR Rabbit Monoclonal Antibody

GTX61706
89364-134EA 556.26 CAD
89364-134
Anti-EGFR Rabbit Monoclonal Antibody
Epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase that, when activated by epidermal growth factor (EGF), affects cell growth and differentiation in normal and cancer cells . Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor . The carboxy terminal tyrosine residues on EGFR, Tyr 1068, Tyr 1148, and Tyr 1173, are the major sites of autophosphorylation, which occurs as a result of EGF binding . EGFR overexpression is exhibited various cancer, such as glioma, colorectal carcinoma, breast carcinoma, and head and neck carcinoma . The phosphorylation level of EGFR is considered one of the important predicators for outcome in non-small cell lung cancer therapy .

Type: Primary
Antigen: EGFR
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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