Anti-FAS Rat Monoclonal Antibody

89351-218EA 487.52 CAD
Anti-FAS Rat Monoclonal Antibody
Fas / APO1 (CD95) is an important member of the tumour necrosis factor (TNF) superfamily involved in membrane-mediated apoptosis. Ligation of Fas by Fas Ligand or an anti-Fas cross-linking antibody, triggers activation of the caspase cascade. Functional impairment of the Fas / Fas Ligand system is associated with the development and progression of malignancies. Fas gene mutations have been suggested to have a role in testicular germ cell tumours. Tumour cells frequently exhibit de novo expression of Fas Ligand, which plays a significant role in local tissue destruction, metastatic spread, and immune escape of the tumor cells. The apoptosis of lymphocytes, which occurs in autoimmune diseases, is usually induced by the Fas/Fas Ligand system. Fas is believed to be involved in various autoimmune diseases including ulcerative colitis, Graves disease, and rheumatoid arthritis. Fas expression on gastric epithelial cells in patients infected with H. Pylori is responsible for the accelerated apoptosis of the cells. Serum Fas Ligand concentration has also been shown to be associated with atherosclerosis and inflammatory disease, in patients with hypertension.

Type: Primary
Antigen: FAS
Clonality: Monoclonal
Host: Rat
Isotype: IgG2a
Reactivity: Cat
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