Anti-HDAC4 Rabbit Monoclonal Antibody

GTX61209
89363-880EA 556.26 CAD
89363-880
Anti-HDAC4 Rabbit Monoclonal Antibody
Histone deacetylase 4 belongs to the histone deacetylase family type 2 which actively deacetylate the 4 core Histones . HDAC4 possesses two repression domains, one composed of the N-terminal 208 residues and the other consist of a deacetylase domain . The N-term will interact with the MADX-box of MEFC2 to negatively regulate expression. Additionally, the deacetylase activity of HDAC4 is subject to negative regulation by its N-terminal domain . HDAC4 is also implicated in the regulation of muscle differentiation. During muscle differentiation, HDC4 is shuttled between nuclear and cytoplasmic compartments. Phosphorylation by CAMK4 at S246, S467 and S632 can control HDAC4 subcellular localization .

Type: Primary
Antigen: HDAC4
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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