Anti-HER2 Rabbit Monoclonal Antibody

GTX61656
89364-112EA 556.26 CAD
89364-112
Anti-HER2 Rabbit Monoclonal Antibody
HER2 / ErbB2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases . The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins . Overexpression of ErbB2 is detected in almost 40% of human breast cancers . Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation . ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

Type: Primary
Antigen: HER2
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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