Anti-HER3 Rabbit Monoclonal Antibody

89364-318EA 556.26 CAD
Anti-HER3 Rabbit Monoclonal Antibody
HER3/ErbB3 is a member of the ErbB/EGF receptor protein tyrosine kinase family . Tyrosine phosphorylation of HER3/ErbB3 depends on its association with other ErbB tyrosine kinases . Phosphorylation sites in the carboxy-terminal tail mediate downstream signaling pathways. HER3/ErbB3 is highly expressed in many cancer cells , and it may work together with other Erb members in tumorigenesis and proliferation . HER/ErbB3 is phosphorylated by EGFR or ErbB2 through dimeric interactions with HER/ErbB3, on Tyrosine 1289, a docking site for phosphatidylinositol 3-kinase .

Type: Primary
Antigen: HER3
Clonality: Monoclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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