Anti-IgM Rat Monoclonal Antibody [clone: LO-MM-9] (Biotin)

Supplier: GeneTex

GTX11659
89358-666EA 323.22 CAD
89358-666
Anti-IgM Rat Monoclonal Antibody [clone: LO-MM-9] (Biotin)
Antibodies
IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenstres are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated.

Recommended Starting Dilutions:ELISA: Use at a concentration of 0.25 µg/mL.Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Secondary
Antigen: IgM heavy chain
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope: Heavy Chain
Host: Rat
Isotype: IgG2a
Reactivity: Mouse
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