Anti-LAT Rabbit Polyclonal Antibody

89361-454EA 535.55 CAD
Anti-LAT Rabbit Polyclonal Antibody
Linker for activation of T cells (LAT) is a 36 kDa transmembrane adapter protein that is tyrosinephosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (Y132, Y171, Y191 and Y226 in human LAT) are crucial for its activity and subsequent signaling to downstream molecules. Tyrosine 191 has been shown to play a key role in T cell activation, and to mediate Grb2 binding and Gads recruitment, thus mediating SLP-76 binding.

Type: Primary
Antigen: LAT
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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