Anti-LAT Rabbit Polyclonal Antibody

GTX24478
89361-454EA 535.55 CAD
89361-454
Anti-LAT Rabbit Polyclonal Antibody
Linker for activation of T cells (LAT) is a 36 kDa transmembrane adapter protein that is tyrosinephosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (Y132, Y171, Y191 and Y226 in human LAT) are crucial for its activity and subsequent signaling to downstream molecules. Tyrosine 191 has been shown to play a key role in T cell activation, and to mediate Grb2 binding and Gads recruitment, thus mediating SLP-76 binding.

Type: Primary
Antigen: LAT
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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