Anti-MCSF1R Goat Polyclonal Antibody

89354-776EA 503.04 CAD
Anti-MCSF1R Goat Polyclonal Antibody
Macrophage Colony Stimulating Factor Receptor is the homodimeric product of the c-fms proto oncogene and maps to chromosome 5 at band 5q33.3. It is a member of the type III subfamily of receptor tyrosine kinases. Other members of this subfamily include Flt-3, the receptor for SCF, and the alpha and beta receptors for PDGF. These receptors are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. Protein kinase C activation induces the proteolytic cleavage of MCSF receptor from the cell surface, resulting in the release of the functional ligand binding extracellular domain. Mature recombinant human MCSF receptor, a 737 amino acid residue protein, has a calculated molecular mass of approximately 81 kDa. MCSF receptor is expressed primarily on cells of the monocyte/macrophage lineage and in various tissues of the developing placenta. During maturation of mononuclear phagocytic cells, the number of MCSF receptors increases to a maximum on mature tissue macrophages. The presence of MCSF receptors on placental trophoblasts and the greatly increased expression of uterine MCSF during pregnancy indicate that it may also play a significant role in placentadevelopment. MCSF receptor binds MCSF with high affinity and is a potent MCSF antagonist. MCSF binding induces receptor homodimerization, resulting in transphosphorylation of specific cytoplasmic tyrosine residues and signal transduction.

Type: Primary
Antigen: MCSF1R
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Goat
Isotype: IgG
Reactivity: Human
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