Myosin-VI is one of the unconventional members of the myosin molecular motor superfamily. The protein has broad tissue expression and has been implicated in endocytosis at both the clathrin-coated and uncoated stages. Regulation of myosin-6 transport has been shown to involve adaptor proteins including GIPC, which contains a PDZ-domain for uncoated vesicle recruitment and Dab2 for clathrin-coated vesicle association. In hair cells of the inner ear, absence of functional myosin-VI protein leads to cell death and deafness.
Type: Primary
Antigen: Myosin VI
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: