Anti-Neutrophil Elastase Rabbit Polyclonal Antibody

89363-146EA 502.52 CAD
Anti-Neutrophil Elastase Rabbit Polyclonal Antibody
Elastases form a subfamily of serine proteases that hydrolyse many proteins in addition to elastin. Neutrophil elastase (elastase 2) hydrolyses proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. Elastase 2 may play a role in degenerative and inflammatory diseases by its proteolysis of collagen IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Type: Primary
Antigen: Neutrophil Elastase
Clonality: Polyclonal
Host: Rabbit
Isotype: IgG
Reactivity: Human
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