Anti-OREXIN B Rabbit Polyclonal Antibody

89356-068EA 487.31 CAD
Anti-OREXIN B Rabbit Polyclonal Antibody
The hypothalamus acts as a major regulatory center involved in the control of feeding behavior and energy homeostasis. Several neuropeptides and proteins have been shown to be involved in the regulation of these processes. Orexin A (hypocretin 1) a 33 amino acid peptide and orexin B(hypocretin 2), a 28 amino acid peptide, are both derived from a common 130 amino acid precursor, prepro-orexin, which is encoded by a gene localized to human chromosome 17q21. Orexin A and Orexin B stimulate food consumption when administered intracerebroventricularly to rats. Orexin gene expression in the brain is highly restricted to distinct populations of neurons located in specific hypothalamic regions, including the lateral hypothalamic area (LHA), a region implicated in feeding behavior. Prepro-orexin mRNA expression is upregulated upon fasting. Immunocytochemical mapping of Orexin A has identified a population of medium sized neurons within the hypothalamus, median eminence and ventral thalamic nuclei of the rat brain. This distribution has been confirmed in the human brain. Orexin-containing neurons diffusely innervate the entire brain, including monosynaptic projections to various regions of the cerebral cortex, limbic system, and brain stem. Orexin A and orexin B bind to and activate two closely related G protein-coupled receptors (GPCRs), termed Orexin 1 (OX1) and Orexin 2 (OX2) receptors. OX1 receptor is selective for orexin A, whereas OX2 receptor is a nonselective receptor for both orexin A and orexin B. OX1 and OX2 mRNA are found in additional brain areas outside the hypothalamus, suggesting that orexin A and B may play additional regulatory roles in the central nervous system, such as arousal, locomotor activity and neuroendocrine functions. Dysfunction of the orexin peptide system has been linked to narcolepsy. Orexin knockout mice exhibit a phenotype strikingly similar to human narcolepsy patients, as well as to canarc 1 mutant dogs, which carry a deletion in the OX2 receptor/Hcrtr2.

Type: Primary
Antigen: OREXIN B
Clonality: Polyclonal
Host: Rabbit
Isotype: IgG
Reactivity: Human
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