Anti-RUNX1 Rabbit Monoclonal Antibody

89364-336EA 585.93 CAD
Anti-RUNX1 Rabbit Monoclonal Antibody
RUNX1 (PEBP2-alpha B, Runt-related transcription factor 1, AML1) is a pivotal transcription factor essential for haematopoietic stem cell generation in the vascular regions of the aorta, vitelline and umbilical arteries, yolk sac and placenta . It binds DNA in cooperation with CBFbeta to activate or repress transcription, dependent upon cellular context and interaction with a variety of co-activators and co-repressors . RUNX1 is required for maturation of megakaryocytes and differentiation of T and B cells . It is one of the most frequent targets of chromosome translocations associated with leukemia . Mutation at the C-terminal region of RUNX1 might predict acute myeloid leukemia transformation .

Type: Primary
Antigen: RUNX1
Clonality: Monoclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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