Anti-PEA15 Rabbit Polyclonal Antibody

89360-376EA 497.79 CAD
Anti-PEA15 Rabbit Polyclonal Antibody
PED/PEA-15 (Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes - 15 kDa) is a widely expressed 15 kDa protein comprised of an N-terminal region containing a canonical Death Effector Domain (DED) sequence and a nuclear export signal, and a C-terminal region containing two serine phosphorylation sites. PED/PEA-15 has been implicated in the regulation of multiple cellular processes including apoptosis, integrin activation, and insulin-sensitive glucose transport in insulin-responsive cells. Phosphorylation of both serine 104 (a Protein Kinase C site) and serine 116 (a substrate of CaMKII and Akt) is required for PED/PEA-15 function.

WB: 1/1000. Detects a band of approximately 15 kDa (predicted molecular weight: 15 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: PEA15
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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