Anti-PRKCA Mouse Monoclonal Antibody [clone: 133]

Supplier: GeneTex
89358-746EA 918.91 CAD
Anti-PRKCA Mouse Monoclonal Antibody [clone: 133]
Protein Kinase c alpha (PKC alpha) is an 80 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell-cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide-dependent kinase-1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy-terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.

Recommended Starting Dilutions:Immunohistology - Frozen: Neat - 1/10Western Blotting: 1/10 - 1/500Not tested in other applications. Optimal dilution / concentration should be determined by the end user.

Type: Primary
Antigen: PRKCA
Clonality: Monoclonal
Clone: 133
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG2a
Reactivity: Human, Mouse, Mammals
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