Anti-EIF2AK2 Rabbit Monoclonal Antibody

GTX61154
89363-850EA 556.26 CAD
89363-850
Anti-EIF2AK2 Rabbit Monoclonal Antibody
Protein kinase R (PKR) is a serine/threonine kinase that is induced by interferon and activated by double-stranded RNA. Upon activation, PKR is autophosphorylated at multiple sites and phosphorylates the α-subunit of the eukaryotic initiation factor-2 eIF2 (eIF2α), inhibiting protein synthesis . PKR controls the activation of several transcription factors and mediates the effects of interferon via its capacity to inhibit protein synthesis . It has been shown that the autophosphorylation sites Thr-446 and Thr-451 in the activation loop of Human PKR are critical for its kinase activity .

Type: Primary
Antigen: EIF2AK2
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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