Anti-RAD17 Rabbit Monoclonal Antibody

89364-262EA 556.26 CAD
Anti-RAD17 Rabbit Monoclonal Antibody
Checkpoint Rad proteins function early in the DNA damage signaling cascade to arrest cell cycle progression in response to DNA damage . There is a direct regulatory linkage between the Rad17 homologue and the checkpoint kinases, ATM and ATR . ATR but not ATM phosphorylates the Rad17 checkpoint protein on Ser635 and Ser645 in vitro. In undamaged synchronized human cells, these two sites were phosphorylated in late G, S, and G/M, but not in early-mid G. Treatment of cells with genotoxic stress induced phosphorylation of Rad17 in cells in early-mid G. This suggests that ATR and Rad17 are essential components of a DNA damage response pathway in mammalian cells .

Type: Primary
Antigen: RAD17
Clonality: Monoclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human
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