Anti-RB1 Mouse Monoclonal Antibody [clone: 172C1094]

Supplier: Genetex
89359-898EA 946.56 CAD
Anti-RB1 Mouse Monoclonal Antibody [clone: 172C1094]
Retinoblastoma gene product (RB) is a tumor suppressor protein and acts as cell cycle regulator. Recently, RB has been shown to play a role in apoptosis. During apoptosis, RB is subjected to cleavage by caspase 3 like protease. Caspase 3 cleaves RB into 48 and 68kDa fragments. Cleavage of RB would make it functionally inactive, causing release of E2F 1. The E2F 1 then may promote apoptosis.

WB: Use at a concentration of 2 ?g/ml. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa). IHC: (see Liu et al, 2005 in Product Citation). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: RB1
Clonality: Monoclonal
Clone: 172C1094
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1
Reactivity: Human
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