Anti-SAA1 Mouse Monoclonal Antibody [clone: 3H62]

Supplier: GeneTex
89360-330EA 965.29 CAD
Anti-SAA1 Mouse Monoclonal Antibody [clone: 3H62]
The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute-phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in-vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed it's importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP.SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a "houekeeping" role in normal human tissues.Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid artheritis.

For ELISA: Use at a concentration of 0.3 ?g/ml (capture coating dose). Allows detection of 1.1 ng/ml of SAA in serum/plasma or 0.6 ng/ml of SAA in medium with an assay range of 0 to 80 ng/ml. Suggested substrate: TMB. For WB: Use at a concentration of 0.1-0.5 ?g/ml to visualize 100 ng/lane of recombinant human SAA. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Type: Primary
Antigen: SAA1
Clonality: Monoclonal
Clone: 3H62
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1
Reactivity: Human
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