Anti-SMAD3 Rabbit Monoclonal Antibody

GTX61361
89363-950EA 556.26 CAD
89363-950
Anti-SMAD3 Rabbit Monoclonal Antibody
Smad proteins belong to a group of intracellular signal transducers and downstream effectors of TGF-β/BMP Signaling. The family consists of nine members that are highly conserved in the N- and C-terminal regions . Smad3 is a key component in intracellular signaling of transforming growth factor beta (TGF-β), an inhibitor for tumor cell proliferation . Smad3 is activated by activin/TGF-β receptors, which form a heteromeric complex with Smad4, translocating to the nucleus and regulating the expression of TGF- β target genes. Interaction of Smad3 with Akt, can initiate TGF- β induced apoptosis and cell cycle arrest . Smad3 expression may be critical in tumor suppression in early stages of gastric carcinogenesis .

Type: Primary
Antigen: SMAD3
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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