Anti-SMITH Antigen Mouse Monoclonal Antibody

89351-388EA 557.58 CAD
Anti-SMITH Antigen Mouse Monoclonal Antibody
The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30% of patients with SLE. This antibody recognizes cross-reactive epitopes on the B'/B and D polypeptides of Sm. It precipitates the small nuclear RNAs U1, U2, U4, U5, and U6 providing direct evidence that the Sm antigen resides on all these RNA-protein complexes.

Type: Primary
Antigen: SMITH Antigen
Clonality: Monoclonal
Host: Mouse
Isotype: IgG3
Reactivity: Drosophila
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