Anti-RANKL Mouse Monoclonal Antibody [clone: 12A668]

Supplier: GeneTex
89359-764EA 934.52 CAD
Anti-RANKL Mouse Monoclonal Antibody [clone: 12A668]
sRANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.

We recommend the following starting dilutions:

For WB: Use at a concentration of 0.5-2 µg/ml.

For IHC-P: Use at a concentration of 5 µg/ml.

For FACS: Use at a assay dependent dilution.

Optimal dilutions should be determined experimentally by the end user.

Type: Primary
Antigen: RANKL
Clonality: Monoclonal
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1
Reactivity: Mouse
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