Anti-SYK Mouse Monoclonal Antibody [clone: SPM147]

Supplier: GeneTex
89351-028EA 724.17 CAD
Anti-SYK Mouse Monoclonal Antibody [clone: SPM147]
SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.

For IHC-P: Use at a dilution of 1-100 for 10 min. at RT. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. For IP: Use at a concentration of 2ug antibody/mg protein lysate. For WB: Use at a concentration of 1 ?g/ml. Predicted molecular weight: 72 kDa.Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher

Type: Primary
Antigen: SYK
Clonality: Monoclonal
Clone: SPM147
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG2a
Reactivity: Human
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