Anti-TRF2 Mouse Monoclonal Antibody [clone: 4A794]

Supplier: Genetex
89359-762EA 980.06 CAD
Anti-TRF2 Mouse Monoclonal Antibody [clone: 4A794]
TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.

ICC: Use at an assay dependent dilution. IP: Use 2?g for 10^6 cells. WB: Use at a concentration of 2 ?g/ml. Detects distinct doublet bands of approximately 66 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: TRF2
Clonality: Monoclonal
Clone: 4A794
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1
Reactivity: Human
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