Anti-USP7 Rabbit Monoclonal Antibody

GTX62530
89364-490EA 556.26 CAD
89364-490
Anti-USP7 Rabbit Monoclonal Antibody
USP7 (Ubiquitin-specific-processing protease 7) is a deubiquitinase that has been shown to regulate the p53-Mdm2 pathway . Cotransfection of p53 and USP7 stabilizes p53 through the removal of ubiquitin moieties from polyubiquitinated p53 . It also counteracts the destabilizing effect of Mdm2 by direct deubiquitination of p53 . Subsequently, USP7 has been shown to deubiquitinate Mdm2 and Mdmx, thereby stabilizing these proteins . USP7 interacts with herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 and Epstein-Barr virus EBNA1. EBNA1 shows a tenfold higher affinity than TP53 and can compete with it for USP7 binding .

Type: Primary
Antigen: USP7
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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