Anti-XTP4 Rabbit Polyclonal Antibody

Supplier: GeneTex

89367-392EA 841.4 CAD
Anti-XTP4 Rabbit Polyclonal Antibody
Certain loci on human chromosome 17q12 are frequently amplified in various types of cancers. One of such loci is PP1R1B-ERBB2-GRB7 which is greatly amplified in gastric and breast cancer. Search of other genes that reside close to this recombination hot spot or ""fragile loci"" led to discovery of several genes, one of these genes is a new theoretical protein MGC14832 is localized on chromosome 17 at cytogenetic location of 17q21.2. The detailed analyses of the amplicon structure in 330 breast tumors samples revealed a 280 kb common region of amplification that contains 10 genes that include 8 known genes. A highly significant association between amplification and expression levels was observed for 6 genes including ERBB2 and 2 uncharacterized hypothetical proteins, MGC9753 and MGC14832, in breast carcinoma and human gastric cancer samples. MGC14832 is located on human chromosome 17q12 and is in the amplicon cluster consist of PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 with in the 120 kb region locus on human chromosome 17q12.

ELISA: Use at a dilution of 1/15,000 - 1/20,000. WB: Use at an assay dependent dilution. Predicted molecular weight: 13.8 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: XTP4
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Fish
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